ciclopirox (Penlac) is an antifungal used to treat onychomycosis,a type of nail fungus.?
Saturday, October 3rd, 2009 at
9:42 am
the direction say to apply the lacquer to each nail daily. will the ciclopirox have a local or system effect? why?
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After you apply the lacquer to your skin, the ciclopirox will penetrate through the epidermis (outer layer of your skin, made up in most areas of the body of 5 layers) into the dermis.
Even under occlusion (which increases absorption), less than 1.5% of the ciclopirox is absorbed into the systemic circulation. Ciclopirox has a short half-life (1.7 hours), so no systemic accumulation occurs and therefore no systemic effect will occur.
To answer your question in a more succinct manner – there is only a small amount of absorption into the systemic circulation (<1.5%) due to the protective function of the skin and the properties of the drug.